The objective of INTEGRA is to bring together all available information within a coherent methodological framework for assessing the source-to-dose continuum for the entire life cycle of substances covering an extensive chemical space. Hence, the major component of INTEGRA will be a unified computational platform that integrates environmental fate, exposure and internal dose dynamically in time. In this way, the platform will be able to differentiate between biomonitoring data corresponding to steady exposure patterns as opposed to acute, one-off exposures. The platform will be largely validated using human biomonitoring data from Europe and the USA. The INTEGRA computational platform will be based on the existing platform developed in the frame of the LRI-B4 INTERA and LRI-B5 TAGS projects extending it to incorporate several advances:
1. Incorporation of ART (and its dermal exposure-integrated version, DART) for assessing occupational exposure, coupled to a generic PK model for linking exposure to internal dosimetry and estimating total body burden
2. Refinement of the TAGS multimedia model to account for multi-scale interactions affecting the environmental transport and fate of chemicals
3. Refinement of the TAGS/INTERA micro-environmental modeling for improved personal exposure assessment.
4. Refinement of the TAGS/INTERA generic PBTK model so as to incorporate life stage changes and physiological and metabolic efficiency change over an individual’s lifetime (from conception till 80 years of age). The model will be able to cover perinatal exposure including exposure routes such as lactation, being practically a mother-fetus interaction model.
5. Inverse modeling for exposure reconstruction and HBM data assimilation.
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